Guidance for waiving tests for pesticide formulationsĬanada Pest Management Regulatory Agency guidance (2013) US Environmental Protection Agency guidance for acute dermal toxicity tests (2016) JaCVAM statement (2014) KoCVAM guideline (2009) Reconstructed human epidermis phototoxicity test method In vitro assays addressing the adverse outcome pathway (AOP) key event on activation of dendritic cellsĮURL ECVAM recommendation (2015) JaCVAM statement (2017) KoCVAM guideline (2017)ģT3 neutral red uptake (NRU) phototoxicity testĮSAC statement (1997) ICH S10 KoCVAM guideline (2007) In chemico assays addressing the adverse outcome pathway (AOP) key event on covalent binding to proteinsĮURL ECVAM recommendation (2013) JaCVAM statement (2015) KoCVAM guideline (2016)Īmino acid derivative reactivity assay (ADRA)ĮURL ECVAM recommendation (2014) JaCVAM statement (2015) KoCVAM guideline (2017) Implementing AOP workflow for skin sensitisationĮxample for predicting skin sensitisation of a mixtureĮxample of how to predict the skin sensitisation potential of aĬhemical by read-across based on an analogue approach US Environmental Protection Agency policy (2018)Įuropean Chemicals Agency guidance Chapter R.7a., R.7.3.4–R.7.3.7 (2017) Use of alternative approaches for skin sensitisation as a replacement for animal testing OECD GD 256 ( Annex I, Annex II), published in 2016 Integrated approaches to testing and assessment (IATA) Guidance on reporting of defined approaches and individual information sources to be used within Guideline on defined approaches on skin sensitisation OECD GD 168 ( Part 1, Part 2), published in 2012 JaCVAM statement (2013) KoCVAM guideline (2017)Īdverse outcome pathway (AOP) for skin sensitisation In vitro skin irritation: Reconstructed human epidermis (RhE) testĮSAC statement (2007) JaCVAM statement (2010) KoCVAM guideline (2014)ĮSAC statement (2008) JaCVAM statement (2013) KoCVAM guideline (2017) ICCVAM report (2002) ESAC statement (2000) JaCVAM statement (2017)ĮSAC statement (2006) JaCVAM statement (2017)ĮSAC statement (2009) JaCVAM statement (2017) ICCVAM report (2002) ESAC statement (1998) JaCVAM statement (2017) In vitro skin corrosion: Reconstructed human epidermis (RhE) test ICCVAM report (1999) ESAC statement (2000) JaCVAM statement (2017) In vitro membrane barrier test Corrositex for skin corrosion Integrated approach on testing and assessment (IATA) for skin corrosion and irritationĬhemical toxicity assessment strategy for skin corrosion and irritationĮuropean Chemicals Agency guidance Chapter R.7a., R.7.2 (2017) ICCVAM report (2006) ESAC statement (2007) JaCVAM statement (2009)ĮSAC statement (2009) ICCVAM report (2010) ICCVAM report (2006) ESAC statement (2007) JaCVAM statements (20) KoCVAM guideline (2011) ICCVAM report (2013) JaCVAM statement (2016) KoCVAM guideline (2017)īovine corneal opacity and permeability (BCOP) test method Short time exposure (STE) in vitro test method Reconstructed human cornea-like epithelium (RhCE) test method (SkinEthic™)ĮSAC statement (2009) JaCVAM statement (2013) Reconstructed human cornea-like epithelium (RhCE) test methodĮSAC statement (2014) JaCVAM statements (20) KoCVAM guideline (2016) US Environmental Protection Agency policy (2015) Use of a testing framework employing cytosensor microphysiometer (CM), BCOP, and the EpiOcular™ model for classification of pesticide products OECD test guideline (TG) 467, published in 2022Įuropean Chemicals Agency guidance Chapter R.7a., R.7.2.8–R.7.2.11 (2017) Guideline on defined approaches on eye irritation OECD guidance document (GD) 263, published in 2019 Integrated approach on testing and assessment (IATA) for serious eye damage and irritation Les fiches de renseignements suivantes sont disponibles en français: The following factsheets are available in French: SKIN IRRITATION ( here, training tool also available here) See here for an 11×17 printable poster describing non-animal test strategies for eye irritation, skin irritation, and skin sensitisation. You can also download a printable version of the table below and skin and eye irritation and corrosion factsheets here. To download a pdf version, click on the format option here: A4 or 8.5×11. Interagency Coordinating Committee on the Validation of Alternative Methods ( ICCVAM) are listed below. Alternative methods endorsed by the Organisation for Economic Co-operation and Development ( OECD), the European Union Reference Laboratory for alternatives to animal testing ( EURL ECVAM), the Japanese Center for the Validation of Alternative Methods ( JaCVAM), the Korean Center for the Validation of Alternative Methods ( KoCVAM), and/or the U.S.
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